Leading science, pioneering therapies
Regulators of normal and aged hematopoiesis

Regulators of normal and aged hematopoiesis

Event Date
11 May 2017 - 12:00 to 13:00
Location
SCRM Seminar Room
Speaker Name
Prof Gerald de Haan
Speaker Organisation
University of Groningen, Netherlands

Gerald de Haan's interest have always focused on the elucidation of the molecular machinery that distinguishes long-term repopulating hematopoietic stem cells from their differentiated progeny This interest has led to papers in which the aging hematopoietic stem cell phenotype was first described, studies on genetic loci that regulate lifespan in mice, genetic studies on loci regulating stem cell-specific transcriptomes and studies in which single stem cells were clonally analyzed. In 2006 his lab showed the importance of Ezh2 for maintaining stem cell pool size and preventing exhaustion. Later studies in his lab focused on other PRC proteins, such as Bmi1 and most recently, the Cbx proteins and microRNA's. His longstanding interest in stem cell aging research has allowed him to lead the team of UMCG scientists that developed and designed the European Research Institute for the Biology of Ageing, of which he is current Director.