Epigenetics and Brain Development group publications

2019

Illingworth R. 2019. Chromatin folding and nuclear architecture: PRC1 function in 3D.Curr Opin Genet Dev. 55:82-90.

McLaughlin KA, Flyamer IM, Thomson JP, Mjoseng HK, Shukla R, Williamson I, Grimes GR, Illingworth R, Adams IR, Pennings S. 2019. DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency

Flyamer IM, Illingworth R, Bickmore WA. 2019. Coolpup.py – a versatile tool to perform pile-up analysis of Hi-C data

2017

NS B, I W, Illingworth R, S B, GR G, P T, WA B. 2017. PARP mediated chromatin unfolding is coupled to long-range enhancer activation

2016

Williamson I, Bickmore WA, Illingworth R. 2016. Polycomb-mediated chromatin compaction weathers the STORMGenome biology 2016.

Thomson JP, Ottaviano R, Unterberger EB, Lempiäinen H, Muller A, Terranova R, Illingworth R, Webb S, Kerr ARW, Lyall MJ et al.. 2016. Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.Cancer Res. 76(10):3097-108.

Illingworth R, Hölzenspies JJ, Roske FV, Bickmore WA, Brickman JM. 2016. Polycomb enables primitive endoderm lineage priming in embryonic stem cells.Elife. 5

2015

Illingworth R, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR, Bickmore WA. 2015. The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.Genes Dev. 29(18):1897-902.

Illingworth R, Gruenewald-Schneider U, De Sousa D, Webb S, Merusi C, Kerr ARW, James KD, Smith C, Walker R, Andrews R et al.. 2015. Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome.Nucleic Acids Res. 43(2):732-44.

2014

Williamson I, Berlivet S, Eskeland R, Boyle S, Illingworth R, Paquette D, Dostie J, Bickmore WA. 2014. Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.Genes Dev. 28(24):2778-91.

Therizols P, Illingworth R, Courilleau C, Boyle S, Wood AJ, Bickmore WA. 2014. Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells.Science. 346(6214):1238-42.

2012

Illingworth R, Botting CH, Grimes GR, Bickmore WA, Eskeland R. 2012. PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.PLoS One. 7(4):e34848.

Clouaire T, Webb S, Skene P, Illingworth R, Kerr A, Andrews R, Lee J-H, Skalnik D, Bird A. 2012. Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.Genes Dev. 26(15):1714-28.

2011

Deaton AM, Webb S, Kerr ARW, Illingworth R, Guy J, Andrews R, Bird A. 2011. Cell type-specific DNA methylation at intragenic CpG islands in the immune system.Genome Res. 21(7):1074-86.

2010

Terrenoire E, McRonald F, Halsall JA, Page P, Illingworth R, A Taylor MR, Davison V, O'Neill LP, Turner BM. 2010. Immunostaining of modified histones defines high-level features of the human metaphase epigenome.Genome Biol. 11(11):R110.

Thomson JP, Skene PJ, Selfridge J, Clouaire T, Guy J, Webb S, Kerr ARW, Deaton A, Andrews R, James KD et al.. 2010. CpG islands influence chromatin structure via the CpG-binding protein Cfp1.Nature. 464(7291):1082-6.

Skene PJ, Illingworth R, Webb S, Kerr ARW, James KD, Turner DJ, Andrews R, Bird AP. 2010. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.Mol Cell. 37(4):457-68.

Illingworth R, Gruenewald-Schneider U, Webb S, Kerr ARW, James KD, Turner DJ, Smith C, Harrison DJ, Andrews R, Bird AP. 2010. Orphan CpG islands identify numerous conserved promoters in the mammalian genome.PLoS Genet. 6(9):e1001134.

2009

Illingworth R, Bird AP. 2009. CpG islands--'a rough guide'.FEBS Lett. 583(11):1713-20.

2008

Illingworth R, Kerr A, Desousa D, Jørgensen H, Ellis P, Stalker J, Jackson D, Clee C, Plumb R, Rogers J et al.. 2008. A novel CpG island set identifies tissue-specific methylation at developmental gene loci.PLoS Biol. 6(1):e22.

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