Developmental origins of blood stem cells and leukaemia group publications

2017

Malouf C, Ottersbach K. 2017. Molecular processes involved in B cell acute lymphoblastic leukaemia.Cell Mol Life Sci.

2016

Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEirik W, Huntly BJ, Ottersbach K. 2016. Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Cell Rep. 16(4):1039-54.

Mascarenhas MI, Bacon WA, Kapeni C, Fitch SR, Kimber G, Cheng SWPriscill, Li J, Green AR, Ottersbach K. 2016. Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.Blood. 127((19)):2298-309.

2015

Rao TNageswara, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN et al.. 2015. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.Stem Cell Res. 14(3):307-22.

Marks-Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, Kang YChan, Knezevic K, Qiao Q, Fitch S et al.. 2015. SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.Mol Cell Biol. 35(12):2165-72.

2014

Mirshekar-Syahkal B, Fitch SR, Ottersbach K. 2014. Concise review: From greenhouse to garden: the changing soil of the hematopoietic stem cell microenvironment during development.Stem Cells. 32(7):1691-700.

2013

Diffner E, Beck D, Gudgin E, Thoms JAI, Knezevic K, Pridans C, Foster S, Goode D, Lim WKhong, Boelen L et al.. 2013. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.Blood. 121(12):2289-300.

Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MFTR, Ferguson-Smith AC et al.. 2013. Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.Haematologica. 98(2):163-71.

Malouf C, Ottersbach K. 2013. The unconventional embryo: immune-restricted potential precedes multipotentiality.Cell Stem Cell. 13(5):509-10.

2012

Spensberger D, Kotsopoulou E, Ferreira R, Broccardo C, Scott LM, Fourouclas N, Ottersbach K, Green AR, Göttgens B. 2012. Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Exp Hematol. 40(7):588-598.e1.

Fitch SR, Kimber GM, Wilson NK, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky A, Dzierzak E, Ottersbach K. 2012. Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis.Cell Stem Cell. 11(4):554-66.

2011

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, S Oram H, Smethurst PA, Wilson NK et al.. 2011. Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Dev Cell. 20(5):597-609.

Robin C, Ottersbach K, Boisset J-C, Oziemlak A, Dzierzak E. 2011. CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.Blood. 117(19):5088-91.

Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich, iv N, Groner Y et al.. 2011. A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.Mol Cell Biol. 31(14):2817-26.

2010

Wilson NK, Timms RT, Kinston SJ, Cheng Y-H, S Oram H, Landry J-R, Mullender J, Ottersbach K, Göttgens B. 2010. Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.Mol Cell Biol. 30(15):3853-63.

Ottersbach K, Dzierzak E. 2010. The placenta as a haematopoietic organ.Int J Dev Biol. 54(6-7):1099-106.

Göttgens B, Ferreira R, Sanchez M-J, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S et al.. 2010. cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Mol Cell Biol. 30(24):5741-51.

Ottersbach K, Smith A, Wood A, Göttgens B. 2010. Ontogeny of haematopoiesis: recent advances and open questions.Br J Haematol. 148(3):343-55.

Li J, Spensberger D, Ahn JSook, Anand S, Beer PA, Ghevaert C, Chen E, Forrai A, Scott LM, Ferreira R et al.. 2010. JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.Blood. 116(9):1528-38.

2009

Peeters M, Ottersbach K, Bollerot K, Orelio C, de Bruijn M, Wijgerde M, Dzierzak E. 2009. Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.Development. 136(15):2613-21.

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