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Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.

TitlePolymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro.
Publication TypeJournal Article
Year of Publication2017
AuthorsIngallina C, Costa PM, Ghirga F, Klippstein R, Wang JT, Berardozzi S, Hodgins N, Infante P, Pollard SM, Botta B, Al-Jamal KT
JournalNanomedicine (Lond)
Volume12
Issue7
Pagination711-728
Date Published2017 Apr
ISSN1748-6963
Abstract

AIM: With the purpose of delivering high doses of glabrescione B (GlaB) to solid tumors after systemic administration, long-circulating GlaB-loaded oil-cored polymeric nanocapsules (NC-GlaB) were formulated.

MATERIALS & METHODS: Synthesis of GlaB and its encapsulation in nanocapsules (NCs) was performed. Empty and GlaB-loaded NCs were assessed for their physico-chemical properties, in vitro cytotoxicity and in vivo biodistribution.

RESULTS: GlaB was efficiently loaded into NCs (∽90%), which were small (∽160 nm), homogeneous and stable upon storage. Further, GlaB and NC-GlaB demonstrated specific activities against the cancer stem cells. Preliminary studies in tumor-bearing mice supported the ability of NC to accumulate in pancreatic tumors.

CONCLUSION: This study provides early evidence that NC-GlaB has the potential to be utilized in a preclinical setting and justifies the need to perform therapeutic experiments in mice.

DOI10.2217/nnm-2016-0388
Alternate JournalNanomedicine (Lond)
PubMed ID28322108
Grant List12-1054 / / Worldwide Cancer Research / United Kingdom
Publication institute
CRM