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Human haematopoietic stem cell development: from the embryo to the dish.

TitleHuman haematopoietic stem cell development: from the embryo to the dish.
Publication TypeJournal Article
Year of Publication2017
AuthorsIvanovs A, Rybtsov S, Ng ES, Stanley EG, Elefanty AG, Medvinsky A
JournalDevelopment
Volume144
Issue13
Pagination2323-2337
Date Published2017 Jul 01
ISSN1477-9129
Abstract

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult haematopoietic system. Understanding how early haematopoietic development occurs is of fundamental importance for basic biology and medical sciences, but our knowledge is still limited compared with what we know of adult HSCs and their microenvironment. This is particularly true for human haematopoiesis, and is reflected in our current inability to recapitulate the development of HSCs from pluripotent stem cells in vitro In this Review, we discuss what is known of human haematopoietic development: the anatomical sites at which it occurs, the different temporal waves of haematopoiesis, the emergence of the first HSCs and the signalling landscape of the haematopoietic niche. We also discuss the extent to which in vitro differentiation of human pluripotent stem cells recapitulates bona fide human developmental haematopoiesis, and outline some future directions in the field.

DOI10.1242/dev.134866
Alternate JournalDevelopment
PubMed ID28676567
Publication institute
CRM