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Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.

TitleErythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate.
Publication TypeJournal Article
Year of Publication2014
AuthorsGrover A, Mancini E, Moore S, Mead AJ, Atkinson D, Rasmussen KD, O'Carroll D, Jacobsen SEirik W, Nerlov C
JournalJ Exp Med
Volume211
Issue2
Pagination181-8
Date Published2014 Feb 10
ISSN1540-9538
KeywordsAnimals, Cell Lineage, Colony-Forming Units Assay, Erythroid Precursor Cells, Erythropoiesis, Erythropoietin, Gene Expression Profiling, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Transgenic, Multipotent Stem Cells, Recombinant Proteins
Abstract

The erythroid stress cytokine erythropoietin (Epo) supports the development of committed erythroid progenitors, but its ability to act on upstream, multipotent cells remains to be established. We observe that high systemic levels of Epo reprogram the transcriptomes of multi- and bipotent hematopoietic stem/progenitor cells in vivo. This induces erythroid lineage bias at all lineage bifurcations known to exist between hematopoietic stem cells (HSCs) and committed erythroid progenitors, leading to increased erythroid and decreased myeloid HSC output. Epo, therefore, has a lineage instructive role in vivo, through suppression of non-erythroid fate options, demonstrating the ability of a cytokine to systematically bias successive lineage choices in favor of the generation of a specific cell type.

DOI10.1084/jem.20131189
Alternate JournalJ. Exp. Med.
PubMed ID24493804
PubMed Central IDPMC3920567
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