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CpG islands--'a rough guide'.

TitleCpG islands--'a rough guide'.
Publication TypeJournal Article
Year of Publication2009
AuthorsIllingworth R, Bird AP
JournalFEBS Lett
Volume583
Issue11
Pagination1713-20
Date Published2009 Jun 05
ISSN1873-3468
KeywordsCpG Islands, DNA Methylation, Gene Silencing, Genomic Imprinting, Humans, Promoter Regions, Genetic, X Chromosome Inactivation
Abstract

Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing. CGI methylation also occurs in normal tissues and is known to function in X-inactivation and genomic imprinting. More recently, differential methylation has been shown between tissues, suggesting a potential role in transcriptional regulation during cell specification. Many of these tissue-specific methylated CGIs localise to regions distal to promoters, the regulatory function of which remains to be determined.

DOI10.1016/j.febslet.2009.04.012
Alternate JournalFEBS Lett.
PubMed ID19376112
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