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Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

TitleBlimp1 regulates the transition of neonatal to adult intestinal epithelium.
Publication TypeJournal Article
Year of Publication2011
AuthorsMuncan V, Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, Weerman MA van den, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR
JournalNat Commun
Volume2
Pagination452
Date Published2011
ISSN2041-1723
KeywordsAnimals, Female, Gene Expression Regulation, Developmental, Intestinal Mucosa, Male, Mice, Mice, Knockout, Mice, Transgenic, Transcription Factors
Abstract

In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.

DOI10.1038/ncomms1463
Alternate JournalNat Commun
PubMed ID21878906
PubMed Central IDPMC3167062
Grant List241344 / / European Research Council / International
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