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Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.

TitleBlimp1 defines a progenitor population that governs cellular input to the sebaceous gland.
Publication TypeJournal Article
Year of Publication2006
AuthorsHorsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E
JournalCell
Volume126
Issue3
Pagination597-609
Date Published2006 Aug 11
ISSN0092-8674
KeywordsAnimals, Animals, Newborn, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cell Lineage, Cell Movement, Cell Proliferation, Cells, Cultured, Epithelial Cells, Gene Expression Regulation, Developmental, Hair Follicle, Hyperplasia, Mice, Mice, Knockout, Mice, Transgenic, Multipotent Stem Cells, Proto-Oncogene Proteins c-myc, Repressor Proteins, Sebaceous Glands, Stem Cells, Transcription Factors
Abstract

Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG and express the transcriptional repressor Blimp1. Using cell-culture studies and genetic lineage tracing, we demonstrate that Blimp1-expressing cells are upstream from other cells of the SG lineage. Blimp1 appears to govern cellular input into the gland since its loss leads to elevated c-myc expression, augmented cell proliferation, and SG hyperplasia. Finally, BrdU labeling experiments demonstrate that the SG defects associated with loss of Blimp1 lead to enhanced bulge stem cell activity, suggesting that when normal SG homeostasis is perturbed, multipotent stem cells in the bulge can be mobilized to correct this imbalance.

DOI10.1016/j.cell.2006.06.048
Alternate JournalCell
PubMed ID16901790
PubMed Central IDPMC2424190
Grant ListG108/500 / / Medical Research Council / United Kingdom
R01 AR031737 / AR / NIAMS NIH HHS / United States
R01 AR031737-24 / AR / NIAMS NIH HHS / United States
R01-AR050452 / AR / NIAMS NIH HHS / United States
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