Ian Wilmut

Position:

Professor Emeritus; Chairman SCRM building

Telephone:

0131 651 9500

ian.wilmut@ed.ac.uk

Biography:

2006-2011, Founding Director, MRC Centre for Regenerative Medicine, University of Edinburgh;
2005-2006, Professor of Reproductive Science, University of Edinburgh;
2000 -2005, Head of Department, Gene Expression and Development, Roslin Institute;
1973-2005, Principal Investigator, Roslin Institute;
1971-1973, Postdoc, ARC Unit of Reproductive Physiology and Biochemistry, Cambridge. The first methods were developed for the deep freeze storage of mammalian embryos.
1967-1971, PhD Darwin College, Cambridge Deep Freeze Preservation of Boar Semen.

Publications

2017

Development of an inducible platform for intercellular protein delivery. Siller, Richard, Dufour Eric, Lycke Max, Wilmut Ian, Jung Yong-Wook, Park In Hyun, and Sullivan Gareth J. , Int J Pharm, 2017 Apr 30, Volume 522, Issue 1-2, p.1-10, (2017)

2016

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly. Xu, Maojia, Stattin Eva-Lena, Shaw Georgina, Heinegård Dick, Sullivan Gareth, Wilmut Ian, Colman Alan, nnerfjord Patrik Ö., Khabut Areej, Aspberg Anders, et al. , Stem Cells Transl Med, 2016 09, Volume 5, Issue 9, p.1171-81, (2016)

2015

Cells: from Robert Hooke to cell therapy - a 350 year journey Hyllner, Johan, Mason Chris, and Wilmut Ian , Philos Trans R Soc Lond B Biol Sci, 2015 Oct 19, Volume 370, Issue 1680, p.20150320, (2015)

Somatic cell nuclear transfer: origins, the present position and future opportunities Wilmut, Ian, Bai Yu, and Taylor Jane , Philosophical Transactions of the Royal Society B: Biological Sciences, Jul-10-2016, Volume 370363394399, Issue 1680, p.20140366, (2015)

Development of a global network of induced pluripotent stem cell haplobanks Wilmut, Ian, Leslie Stephen, Martin Nicholas G., Peschanski Marc, Rao Mahendra, Trounson Alan, Turner David, Turner Marc L., Yamanaka Shinya, and Taylor Craig J. , Regenerative Medicine, Jan-05-2015, Volume 10, Issue 3, p.235 - 238, (2015)

2014

From germ cell preservation to regenerative medicine: an exciting research career in biotechnology. Wilmut, Ian , Annu Rev Anim Biosci, 2014 Feb, Volume 2, p.1-21, (2014)

Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells Andrews, Peter W., Cavanagro Joy, Deans Robert, Feigel Ellen, Horowitz Ed, Keating Armand, Rao Mahendra, Turner Marc, Wilmut Ian, and Yamanaka Shinya , Nature Biotechnology, May-08-2014, Volume 32, Issue 8, p.724 - 726, (2014)

2013

Using human induced pluripotent stem cells to treat retinal disease. Borooah, S, Phillips M J., Bilican Bilada, Wright A F., Wilmut Ian, Chandran S, Gamm D, and Dhillon B , Prog Retin Eye Res, 2013 Nov, Volume 37, p.163-81, (2013)

A tribute to Keith Campbell: the birth of the first clone of an adult vertebrate, "Dolly" the sheep. Wilmut, Ian , Cell Reprogram, 2013 Oct, Volume 15, Issue 5, p.339-43, (2013)

Toward the development of a global induced pluripotent stem cell library. Turner, Marc L., Leslie Stephen, Martin Nicholas G., Peschanski Marc, Rao Mahendra, Taylor Craig J., Trounson Alan, Turner David, Yamanaka Shinya, and Wilmut Ian , Cell Stem Cell, 2013 Oct 3, Volume 13, Issue 4, p.382-4, (2013)

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Serio, Andrea, Bilican Bilada, Barmada Sami J., Ando Dale Michael, Zhao Chen, Siller Rick, Burr Karen, Haghi Ghazal, Story David, Nishimura Agnes L., et al. , Proc Natl Acad Sci U S A, 2013 Mar 19, Volume 110, Issue 12, p.4697-702, (2013)

Quantitative evaluation of reference genes for real-time PCR during in vitro maturation of ovine oocytes. O'Connor, T, Wilmut Ian, and Taylor J , Reprod Domest Anim, 2013 Jun, Volume 48, Issue 3, p.477-83, (2013)

2012

Retrospective. Keith Campbell (1954-2012). Wilmut, Ian , Science, 2012 Dec 21, Volume 338, Issue 6114, p.1553, (2012)

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Bilican, Bilada, Serio Andrea, Barmada Sami J., Nishimura Agnes L., Sullivan Gareth, Carrasco Monica, Phatnani Hemali P., Puddifoot Clare A., Story David, Fletcher Judy, et al. , Proc Natl Acad Sci U S A, 2012 Apr 10, Volume 109, Issue 15, p.5803-8, (2012)

SUMOylation of HNF4α regulates protein stability and hepatocyte function. Zhou, Wenli, Hannoun Zara, Jaffray Ellis, Medine C. N., Black James R., Greenhough Sebastian, Zhu Liang, Ross James A., Forbes Stuart J., Wilmut Ian, et al. , J Cell Sci, 2012 Aug 1, Volume 125, Issue Pt 15, p.3630-5, (2012)

2011

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Ruzov, Alexey, Tsenkina Yanina, Serio Andrea, Dudnakova Tatiana, Fletcher Judy, Bai Y, Chebotareva Tatiana, Pells Steve, Hannoun Zara, Sullivan Gareth, et al. , Cell Res, 2011 Sep, Volume 21, Issue 9, p.1332-42, (2011)

Rat eggs cannot wait: Spontaneous exit from meiotic metaphase-II arrest. Chebotareva, Tatiana, Taylor Jane, Mullins John J., and Wilmut Ian , Mol Reprod Dev, 2011 Oct-Nov, Volume 78, Issue 10-11, p.795-807, (2011)

Biomedical and social contributions to sustainability. Wilmut, Ian, Wongtawan Tuempong, Quigley Mindy, and Sullivan Gareth , Philos Trans A Math Phys Eng Sci, 2011 May 13, Volume 369, Issue 1942, p.1730-47, (2011)

Nuclear transfer to eggs and oocytes. Gurdon, J B., and Wilmut Ian , Cold Spring Harb Perspect Biol, 2011 Jun, Volume 3, Issue 6, (2011)

Histone H4K20me3 and HP1α are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. Wongtawan, Tuempong, Taylor Jane E., Lawson Kirstie A., Wilmut Ian, and Pennings Sari , J Cell Sci, 2011 Jun 1, Volume 124, Issue Pt 11, p.1878-90, (2011)

The evolving biology of cell reprogramming. Wilmut, Ian, Sullivan Gareth, and Chambers Ian , Philos Trans R Soc Lond B Biol Sci, 2011 Aug 12, Volume 366, Issue 1575, p.2183-97, (2011)

2010

Proteome of mouse oocytes at different developmental stages. Wang, Shufang, Kou Zhaohui, Jing Zhiyi, Zhang Yu, Guo Xinzheng, Dong Mengqiu, Wilmut Ian, and Gao Shaorong , Proc Natl Acad Sci U S A, 2010 Oct 12, Volume 107, Issue 41, p.17639-44, (2010)

Induced pluripotent stem cells: epigenetic memories and practical implications. Sullivan, Gareth, Bai Y, Fletcher Judy, and Wilmut Ian , Mol Hum Reprod, 2010 Dec, Volume 16, Issue 12, p.880-5, (2010)

The comparison between conditioned media and serum-free media in human embryonic stem cell culture and differentiation. Hannoun, Zara, Fletcher Judy, Greenhough Sebastian, Medine C. N., Samuel Kay, Sharma Ruchi, Pryde Anne, Black James R., Ross James A., Wilmut Ian, et al. , Cell Reprogram, 2010 Apr, Volume 12, Issue 2, p.133-40, (2010)

What are the limits to cell plasticity? Taylor, Jane, Wilmut Ian, and Sullivan Gareth , Cell Res, 2010 May, Volume 20, Issue 5, p.502-3, (2010)

Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Sullivan, Gareth, Hay David C., Park In-Hyun, Fletcher Judy, Hannoun Zara, Payne Catherine, Dalgetty Donna, Black James R., Ross James A., Samuel Kay, et al. , Hepatology, 2010 Jan, Volume 51, Issue 1, p.329-35, (2010)

A new title and a new focus: Cellular Reprogramming. Wilmut, Ian , Cell Reprogram, 2010 Feb, Volume 12, Issue 1, p.1, (2010)

2009

A decade of progress since the birth of Dolly. Wilmut, Ian, Sullivan Gareth, and Taylor Jane , Reprod Fertil Dev, 2009, Volume 21, Issue 1, p.95-100, (2009)

Clinically failed eggs as a source of normal human embryo stem cells. de Sousa, Paul, Gardner John, Sneddon Sharon, Pells Steve, Tye Britt Jorgensen, Dand Pawlina, Collins Daniel M., Stewart Karen, Shaw Lisa, Przyborski Stefan, et al. , Stem Cell Res, 2009 May, Volume 2, Issue 3, p.188-97, (2009)

Cloning and expression of sheep DNA methyltransferase 1 and its development-specific isoform. Taylor, Jane, Moore Hannah, Beaujean Nathalie, Gardner John, Wilmut Ian, Meehan Richard, and Young Lorraine , Mol Reprod Dev, 2009 May, Volume 76, Issue 5, p.501-13, (2009)

2008

Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Bru, Thierry, Clarke Catriona, McGrew Michael J., Sang Helen M., Wilmut Ian, and J Blow Julian , Exp Cell Res, 2008 Aug 15, Volume 314, Issue 14, p.2634-42, (2008)

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