There is no better way of learning about our PhD programme than hearing directly from PhD students studying at CRM.
Watch our film, CRM students reflect on their PhD experience.
I study hippocampal neurogenesis, which is a normal process by which healthy neural stem cells create new brain cells throughout life. The hippocampus is a brain area vital for learning, memory and emotion, but neurogenesis here is disordered in many psychiatric and neurological diseases. Understanding the mechanisms which regulate hippocampal neurogenesis may therefore help develop new treatments for cognitive and emotional symptoms of brain disease.
I chose a lab-based topic because I think psychiatry in the 21st century needs to be scientifically fluent. I realise now how far apart clinical and basic science training are, from skillset to mind-set. Yet in order to develop effective new treatments for these very challenging brain diseases, both traditions will have to work collaboratively. By training in a world-class scientific environment I hope to be able in some small way to help bridge the 'translatability gap', and ultimately help patients.
The PhD programme at CRM is busy but well run and rewarding. The seminars attract top-quality speakers and there are too many other opportunities to list. Socially the 'buzz' is excellent and the centre is a beautiful place to work.
Stem cell technologies have the potential to transform psychiatric treatment. I'm lucky to be working at the cutting edge of this field in an intellectual environment that stimulates as much as it challenges.
I graduated as a vet from Liverpool University in 2008 and spent a year working in small animal practice in the Peak District, before moving to USA to complete an internship at the Veterinary Medical Centre in Minnesota. I returned to Edinburgh to do a residency in Small Animal Internal Medicine, and qualified as a Diplomate of the European College in 2014, after which I secured funding as an ECAT-V CRUK Clinical Fellow to do my PhD based at the MRC Centre for Regenerative Medicine.
I am studying the role of stem cells in blood cancer, more specifically acute myeloid leukaemia. My group has previously shown in mice that a protein called Cited2 is required for normal blood stem cells to become cancerous. We also know that levels of Cited2 are increased in human patients with blood cancer. In my project I am investigating how Cited2 acts to promote the development of blood cancer.
In addition to my work as a vet and research scientist I am a keen fellrunner, and enjoy competing as a member of Carnethy Hill Running Club, Edinburgh. Fellrunning allows me to get out into the hills on a daily basis in spite of a busy work life, and the enjoyment I derive from it motivates me to keep it up, ensuring a work-life balance. In 2015 I became the ladies’ British Fell Running Champion, and in 2016 I have been focusing on some longer challenges, including the Bob Graham Round, a 66-mile circuit of 42 peaks in the Lake District. If you'd like to know more about my fellrunning adventures follow me on Twitter or read my blog.
During my study I developed a passion for research into liver regeneration and closely followed the work of the Forbes’ group. Prof Forbes’ group appealed to me because of their innovative ideas and quality of their research. When I noticed Prof Forbes was recruiting for a PhD position to study liver regeneration in bile ducts I jumped at the chance. I went through all the admission procedures and fortunately was selected!
As part of the interview process they offered me to visit the centre and I was blown away by the SCRM building, the incredible facilities and the stimulating intellectual environment. The atmosphere in the group (and between groups at CRM) is really enriching and collaborative: ideas flow easily on a daily basis. Communication, collaboration and the sense of community are very strong elements at CRM. The variety of internal and external seminars, conferences and courses is very inspirational and helps to develop my own conceptual thinking.
I had a baby during the third year of my PhD program and took six months maternity leave to take care of him. So far my experience of being a mum and doing my thesis has been incredible. My labmates made sure that my research could continue when I returned to work after giving birth. And I was very fortunate to have a great supervisor that understands what having a baby implies.
Being a mum and developing a career in science can be overwhelming but the supportive faculty and the flexibility of my colleagues and supervisor has been wonderful! Having been inspired by careers of other students and post docs at CRM, I hope to successfully complete my PhD, publish in high impact journals and kick-start my future career in science. In the meantime, working at CRM with top leaders in regenerative medicine is a unique experience.
In 2011 I graduated from the University of Edinburgh with a BSc in Biomedical Sciences with Reproductive Biology Honours. After a working for a year in New Zealand, I returned to University of Edinburgh to do an MSc in Integrative Neuroscience, followed by a PhD at CRM.
The University is well known for its cutting edge research, making it a natural choice for me when choosing where to do a PhD. The CRM specifically seemed an excellent platform to further study the exciting and fast paced research area of stem cells and regenerative medicine. In addition, the City of Edinburgh is also hard to beat with stunning scenery, historic landmarks and friendly international atmosphere; it doesn’t take long until you feel at home.
The two best things about CRM are the people and the opportunities. As a new student it is easy to feel out of your depth, however at the CRM they did so much to put us at ease. In the first couple of months all the new starts had discussion groups with many of the PIs at the centre. These invaluable tutorials got us up to speed with the current research occurring in the centre whilst also allowing the first years to get to know each other better, and ultimately form close friendships.
There is such a friendly atmosphere here at the CRM, with an excellent support network consisting not only fellow students but also administrative staff, research technicians, Postdocs and PIs. Regularly there are many networking events which allow interaction between other institutes within University of Edinburgh and give opportunity for collaboration.
Since starting 9 months ago I have had many opportunities to develop academically, in particular attending weekly seminars lead by international speakers has been a highlight. In addition PhD students are encouraged to meet the speaker and discuss ideas about their research topic, something I have thoroughly enjoyed.
Overall the PhD program at CRM offers a brilliant platform to excel in the diverse, exciting and challenging area of stem cells and regenerative medicine research.
Harsh completed his PhD in the Blackburn lab in 2015.
For some, doing a PhD is an obvious choice. While for others, like me, it is more difficult to decide if a PhD is the right thing to do. Unless you have had a demanding professional job previously, a PhD is unlike anything you have done before. Doing a PhD is exciting, exhilarating, an excellent learning process, a brilliant opportunity for personal development, and possibly one of the best things for career enhancement. At the same time, a PhD is very demanding physically, mentally, and intellectually. It requires strong dedication and persistence. Everyone has their own unique PhD experience, which depends on a number of different factors. The research centre and the lab you choose for your PhD are very important factors in that equation.
The focus at CRM is to combine excellent basic science and translational research. This unique combination gives CRM an advantage over most other centres across the UK. I have seen this being recognized and appreciated by both academic and industry sectors. The student training program for first year PhD students will help you develop basic skills like reading scientific literature, critical thinking, and a good understanding of various different research areas (from cell and molecular biology to stem cells biology and translation research), and I really gained from this experience. During your PhD, you will have the opportunity to learn from and work with some of the leading figures in these research areas. That experience is definitely priceless!
Being at CRM, you are part of a much bigger community of The University of Edinburgh. The University has a strong history of excellent life sciences and medical research and continues to be highly ranked globally, currently 17th worldwide. There are also various organizations within the University that support students’ personal and professional development, like IAD, Launch.ed, and BioDocSoc to mention just a few. The key is to make the most of what is available to you. Investing time in gaining additional skills outside the lab will definitely help if you are considering a non-academic career. However, make sure that the time invested does not adversely affect your PhD; After all, it is about research more than anything else.
So, how have I experienced my journey as a PhD student? I have enjoyed being part of the vibrant culture at CRM and the University in general. It has definitely been an amazing learning experience. I have had the opportunity to lead a student society with EUSA, organize various events as a member of CRM’s Social Committee, and I have represented students on the School of Biological Sciences’ student and staff liaison board. Thanks to the communications team at CRM, I have been involved in public engagement activities such as workshops for teachers. The IAD and Launch.ed have been fundamental in helping me learn about entrepreneurship. Thanks to their support I won two business idea competitions and am now exploring the possibility of turning this idea into reality. I have met some really amazing people during my PhD who continue to inspire me to give my best at everything I do. Finally, and most important, I have gained valuable knowledge and technical skills in stem cells and regenerative medicine research which will be extremely useful in my future career, regardless of which career path I choose.
I moved from Poland to Edinburgh in 2005 to study Microbiology and Biotechnology (BSc) and later on Drug Design and Biomedical Sciences (MSc). When I heard about the field of stem cells and regenerative medicine and the impact it might have on shaping the future of medicine, I decided to continue my career by doing a PhD in this area. I was lucky enough get a place in Dr David Hay’s lab at the MRC Centre for Regenerative Medicine (CRM). He works on improving the derivation and functional use of liver cells from pluripotent stem cells.
CRM is not just a scientific institute with high quality equipment that helps you develop basic technical skills, the centre also helps you to improve your transferable skills, such as critical thinking, scientific writing, public speeches and public engagement, as well as time management and organisational skills to help you plan your projects independently. As part of my PhD I’ve been involved in ten publications and have presented my work at conferences in Canada, the UK, The Netherlands and Sweden. What is more, at the Centre you’re exposed to top quality research and have a chance to discuss your work with the best experts in the field over coffee. What more do you need?
If you're worried that taking up a career in academia means you're stuck in the laboratory all night and that it involves many social and personal sacrifices, rest assured. Yes, it certainly requires dedication. But if you are committed it doesn't always have to be like that. Alongside my career in science, I also worked in the fashion industry: I was associated with Scotland's largest modelling agency, Model Team. During my PhD I managed to do different fashion shows, take part in a variety of photoshoots, fashion shows and artistic projects.
During my undergraduate studies in Ireland, as part of my Biotechnology degree I was exposed to the exciting potential of stem cells and the research being carried out on this topic. I had undertaken a number of research projects during my studies, including a summer placement at the University of California, San Francisco where I enjoyed the experience of working in a fast-paced, high-impact research environment.
Upon my return to Ireland I began to investigate potential PhD opportunities, with a specific focus on stem cell biology. I was attracted to CRM because of its history at the forefront of stem cell discovery and the wide scope of the research carried out in a single location. I knew it would be an invaluable chance to study in a world-leading research environment and gain exposure to all aspects of stem cell biology including embryonic development, adult stem cells and therapeutic applications of stem cells.
The level of research carried out at CRM is extremely high, and while this was daunting at the beginning of my studies, I quickly learned that help was always at hand from both peers and senior colleagues and I gained experience in a wide variety of scientific techniques. Through regular lab and group meetings and the internal seminar programme I was given the chance to present and discuss my work and any problems my project had encountered. The feedback from these presentations was crucial in ensuring my research was accurate, of interest to the wider scientific community and high-impact. The CRM also regularly hosts seminars from high-profile researchers from around the world, and students are encouraged to discuss their findings and network with these leading scientists.
During my studies at CRM, I published my research as first-author in the journal Nature. Importantly, I worked with members of my lab as well as colleagues in the Centre and overseas on this research, reflecting the open and collaborative nature of CRM. I worked very closely with the communication team to produce a press release and background paper covering this publication and enjoyed the opportunity to explain the importance of this work to a wider audience. I had previously worked with this team as students at CRM are encouraged to carry out scientific engagement with the public. This broadened my research experience as I gained an insight into how science is viewed by the public and also how important this work is for patients and their families. I enjoyed my time studying in the multi-national environment of CRM, and would thoroughly recommend it as a place to begin a research career.