Stem Cells Transl Med
New study shows a potential future treatment for paracetamol overdose and that stem cell derived liver cells can act as a good model of drug toxicity in the liver.
Three key molecules, Sonic Hedgehog, Stem Cell factor and Noggin, interact together to generate blood stem cells in the embryo. Prof Medvinsky: "This brings us one step closer to making them in the lab for treatments".
Research by Dr. Katrin Ottersbach shows that embryonic blood stem cells are resistant to the JAK2V617F mutation, normally associated with the development of myeloproliferative blood disorders (MPD) in adults.
Dr Gillian Morrison: Our works shows how we can accurately instruct a cell what to become by controlling the signals it receives. By studying this we aim to develop efficient protocols to cells in a dish towards specialised cell types such as beta cells to treat Diabetes.